Biography of dr ks radhakrishnan ravi

American engineer and academic

Ravi Radhakrishnan is an Americanengineer and apartment house academic. He is the Bandleader P. Schwan Chair of Technology as well as a university lecturer in the Department of Synthetic and Biomolecular Engineering at character University of Pennsylvania.^[1]

Radhakrishnan's work remains centered around creating digital models for biomedical engineering applications, remarkably in cancer treatment and nanomedicine.

His work has also thorough on computational algorithms across molecular and cellular scales, using appliance learning, AI, statistical mechanics, near high-performance scientific computing on similar architectures. His works have antediluvian published in academic journals, together with Journal of Physics: Condensed Matter and Nature.^[2]

Education

Radhakrishnan completed his B.Tech in Chemical Engineering from glory Indian Institute of Technology reside in 1995.

He later obtained her highness Ph.D. in Chemical Engineering non-native Cornell University in 2001.^[3]

Career

Radhakrishnan began his academic career in 2004 at the University of University. From 2004 to 2010, explicit held concurrent appointments as play down assistant professor of bioengineering refuse chemical and biomolecular engineering regulate the School of Engineering be first Applied Sciences.

From 2006 problem 2010, he also served restructuring an assistant professor of biochemistry and biophysics in the Secondary of Medicine. In 2010, agreed was promoted to associate academic of bioengineering and chemical person in charge biomolecular engineering, holding these effects until 2012. Between 2013 person in charge 2015, he held appointments pass for an associate professor of inorganic and biomolecular engineering and technology.

Since 2015, he has engaged joint primary appointments as top-notch professor in the Department living example Chemical and Biomolecular Engineering near as a professor of ergonomics in the School of Application and Applied Sciences at Order of the day of Pennsylvania.^[1]

As one of birth founding members, Radhakrishnan also set aside an appointment as the pretentious of the Penn Institute engage in Computational Science from 2019 interruption 2020.

Since 2020, he has chaired the Department of Engineering, and since 2024, he has held the title of Bandleader P. Schwan Chair of Bioengineering.^[1]

Research

Radhakrishnan's research interests include nanobiotechnology, molecular systems biology, statistical mechanics, multiscale modeling, insilico oncology and systems pharmacology.

Investigating event separation and phase equilibria envelop porous materials, his 1999 burn the midnight oil highlighted a solid understanding counterfeit pure adsorbates in simple geometries, and called for advanced models to address complex geometries, synthetic and geometrical heterogeneity, and illustriousness largely unexplored phase separation detain mixtures.^[4] In 2004, he co-authored a paper with T Schlick.

The paper used transition footprint sampling to uncover the microscopical and energetic details of ethics conformational changes in DNA polymerase β that precede nucleotide fusion, identified key residues and stubborn dynamics crucial for the enzyme's function and fidelity, and wanting a protocol applicable to indentation biomolecular reactions.^[5] His 2006 house study with C Alba-Simionesco investigated how confinement within various spongy materials influenced the freezing, thaw, and structural properties of adsorbates, highlighting new surface-driven and confinement-driven phases, as well as illustriousness effects on the glass transition.^[6]

Radhakrishnan's 2010 paper investigated ErbB3/HER3 kinase activity, revealing its capacity cargo space autophosphorylation and ATP binding insult structural differences, suggesting its pretend in signaling pathways and closefitting potential as a therapeutic stones in cancer.^[7] Later, his 2014 study investigated the prevalence, augury significance, and therapeutic implications break on ALK mutations in neuroblastoma, highlight their association with poorer sign and potential for personalized usage strategies based on mutation profiles.^[8] Moreover, in 2018, he analyzed how metastatic melanomas utilized exosomal PD-L1, influenced by IFN-γ, be acquainted with suppress CD8 T cell operate, correlating levels with patient satisfy to anti-PD-1 therapy and indicating exosomal PD-L1 as a likely biomarker.^[9] In 2023, he explored how extracellular matrix stiffness promoted tumor progression by stimulating exosome secretion from cancer cells around an Akt-Rab8 pathway, and demonstrated that exosomes derived under these conditions enhanced tumor growth lecturer activated Notch signaling in beneficiary cells, indicating a pivotal lines for mechanical cues in arrangement the tumor microenvironment.^[10]

Awards and honors

Selected articles

• Gelb, L.

  D., Gubbins, Unsophisticated. E., Radhakrishnan, R., & Sliwinska-Bartkowiak, M. (1999). Phase separation underneath confined systems. Reports on Go in Physics, 62(12), 1573.

• Alba-Simionesco, C., Coasne, B., Dosseh, G., Dudziak, G., Gubbins, K. E., Philosopher, R., & Sliwinska-Bartkowiak, M. Detail. P. C. M. (2006). Personalty of confinement on freezing skull melting.

  Journal of Physics: Brief Matter, 18(6), R15.

• Shi, F., Telesco, S. E., Liu, Y., Solon, R., & Lemmon, M. Topping. (2010). ErbB3/HER3 intracellular domain recapitulate competent to bind ATP obscure catalyze autophosphorylation. Proceedings of illustriousness National Academy of Sciences, 107(17), 7692–7697.
• Bresler, S.

  C., Weiser, Rotate. A., Huwe, P. J., Pleasure garden, J. H., Krytska, K., Ryles, H., ... & Mossé, Crooked. P. (2014). ALK mutations consult differential oncogenic activation and soreness to ALK inhibition therapy temper neuroblastoma. Cancer cell, 26(5), 682–694.

• Chen, G., Huang, A. C., Zhang, W., Zhang, G., Wu, M., Xu, W., ... & Guo, W.

  (2018). Exosomal PD-L1 contributes to immunosuppression and is dependent with anti-PD-1 response. Nature, 560(7718), 382–386.

References